Protein : ADAM17

Hugo ID

195

Name

ADAM17

Description

a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme)

Notes

expression occurs in response to oxygen glucose deprivation, may play a role in inhibition of apoptosis via induction of TNF-alpha release [RGD]

Owner

Public

URN

urn:agi-llid:6868

Connectivity

343


Source

Curated


GenBank ID

NC_000002

NM_003183

NP_003174

NT_005334

NW_927719

AC_000045

AC073195

AAX93142

AC080162

AAY14859

AC092206

AAX93091

AY422721

BC062687

AAH62687

BM725368

BQ186514

BX339672

CN258241

U69611

AAB51514

U69612

AAB53014

U86755

AAB51586

U92649

AAC39721

P78536

Q53RF5

Q53RS1

Q53S40

Q6P5T8

NC_000078

NM_009615

NP_033745

NT_039548

NW_001030491

NW_020984

AC_000034

AC140457

AC156032

AF056345

AAC62934

AF056346

AF056347

AF056348

AF056349

AF056350

AF056351

AF056352

AF056353

AF056354

AF056355

AF056356

AF056357

AF056358

AF056359

AB021709

BAA78578

AJ007365

CAA07480

AK137183

AK137693

BAE23464

AK139471

BAE24023

AK142441

AK144161

BAE25740

AK149288

BAE28792

AK149614

BAE28991

AK165739

BAE38362

AK211820

BC026052

BC094655

AAH94655

BC114999

AAI15000

BE980579

BG082857

C76810

C76813

CA325381

CX220689

U69613

AAD09627

U69614

AAD09628

Q505A7

Q9Z0F8

NC_005105

NM_020306

NP_064702

NW_001084845

NW_047758

AC_000074

AJ012603

CAA10072

Q9Z1K9


LocusLink ID

6868

11491

57027


Organism

Homo sapiens

Mus musculus

Rattus norvegicus


OMIM ID

603639


Alias

TACE

cSVP

CD156b

MGC71942

ADAM metallopeptidase domain 17

snake venom-like protease

TNF-alpha converting enzyme

a disintegrin and metalloproteinase domain 17

a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme)

a disintegrin and metalloprotease domain 17

TNF-alpha converting enzyme precursor


GO ID

0046872

0004222

0005515

0008270

0007219

0007267

0006508

0005887

0016020

0016787

0008237

0008233

0004872

0007229

0005737

0005578

0016021

0005178

0006916

0016337

0006509

0016485

0005925

0001726


Swiss-Prot Accession

P78536

Q53RF5

Q53RS1

Q53S40

Q6P5T8

Q505A7

Q9Z0F8

Q9Z1K9


Unigene ID

Hs.404914

Mm.27681

Rn.144585


RGD ID

620404


MGI ID

1096335


Cell Localization

Extracellular


Microarray ID

205745_x_at

213532_at

205746_s_at

1226_at

41601_at


Pathway

integrin alpha5beta1

Notch -> CREB1 signaling pathway

Notch -> ELK1-SRF signaling pathway

Notch -> ELK4-SRF signaling pathway

Notch -> MYC signaling pathway

Notch -> TCF3 signaling pathway

NOTCH1 -> EP300 signaling pathway

NOTCH1 -> LEF1 signaling pathway

NOTCH1 -> MEF2C signaling pathway

NOTCH1 -> MYOD1 signaling pathway

NOTCH1 -> NF-kB signaling pathway

NOTCH1 -> SMAD3 signaling pathway

Notch -> CBF1 signaling pathway








Group

Extracellular matrix

Proteases

cell-cell adhesion

cell-cell signaling

integrin-mediated signaling pathway

Notch signaling pathway

anti-apoptosis

proteolysis

protein processing

membrane protein ectodomain proteolysis

membrane

ruffle

cytoplasm

integral to membrane

integral to plasma membrane

focal adhesion

extracellular matrix (sensu Metazoa)

protein binding

metal ion binding

zinc ion binding

integrin binding

hydrolase activity

peptidase activity

metallopeptidase activity

metalloendopeptidase activity

receptor activity