ProtModification :

Mechanism unknown
Owner Public
URN urn:agi-ProtModification:inout-urn:agi-protfc:12921105:out-urn:agi-llid:4851::positive
Entities Gamma-secretase --+> NOTCH1
References 1
Connectivity 2
Effect positive

MedLine Reference 15247291:0
Sentence The intramembranous cleavage of Alzheimer beta-amyloid precursor protein and the signaling receptor Notch is mediated by the presenilin (PS, PS1/PS2)-gamma-secretase complex, the components of which also include nicastrin, APH-1, and PEN-2.
Source Curated