DirectRegulation :

Owner Public
URN urn:agi-DirectRegulation:inout-urn:agi-llid:6868:out-urn:agi-llid:4851::positive:direct interaction
Entities ADAM17 --+> NOTCH1
References 1
Connectivity 2
Effect positive
Mechanism direct interaction

Sentence Notch1 Interacts with ADAM17 but Not ADAM10 Although protein studies have provided evidence that ADAM 17 (TACE) cleaves N1 (Brou et al ., 2000 ; Mumm et al ., 2000 ), genetic studies in flies (Pan and Rubin, 1997 ; Lieber et al ., 2002 ) and mice (Hartmann et al ., 2002 ) are more consistent with a role for ADAM10/Kuzbanian (Kuz) in Notch signaling.
Source Curated
MedLine Reference 15574878:1245