Binding :

Connectivity 2
Owner Public
URN urn:agi-Binding:inout-urn:agi-llid:4851:inout-urn:agi-llid:182:
Entities JAG1 ---- NOTCH1
References 22

MedLine Reference 10934472:3
Sentence Lfng does not prevent binding of soluble Jagged1 or Delta1 to Notch1-expressing cells.
Organism Mus musculus

MedLine Reference 10551863:7
Sentence Finally, solid-phase binding assay showed that Jagged1 binds to Notch1 and Notch3 in addition to Notch2, suggesting that mJagged1 is a ligand for multiple Notch receptors.
Organism Mus musculus
CellLineName BaF3

MedLine Reference 15574878:5
Sentence Our data support the idea that fringe glycosylation increases Delta1 binding to potentiate signaling, but we propose that although fringe glycosylation does not reduce Jagged1 binding to Notch1, the resultant ligand-receptor interactions do not effectively promote Notch1 proteolysis required for activation of downstream signaling events.
Organism Mus musculus

CellLineName NIH 3T3

CellLineName NIH 3T3

Organism Mus musculus
CellLineName BaF3

Organism Mus musculus

Organism Mus musculus
CellLineName BaF3

Organism Mus musculus

MedLine Reference 11427524:10194
Journal J. Biol. Chem
Journal Reference v276 i34 p32022
Journal Link http://www.jbc.org/cgi/content/full/276/34/32022
Organism Mus musculus

MedLine Reference 15292061:10201
Journal Blood
Journal Reference v104 i12 p3697
Journal Link http://www.bloodjournal.org/cgi/content/full/104/12/3697

MedLine Reference 12496248:10335
Journal J. Biol. Chem
Journal Reference v278 i10 p8771
Journal Link http://www.jbc.org/cgi/content/full/278/10/8771

MedLine Reference 15585829:10100
Journal J. Immunol
Journal Reference v173 i12 p7109
Journal Link http://www.jimmunol.org/cgi/content/full/173/12/7109

MedLine Reference 12496248:1050
Sentence Furthermore, soluble forms of the extracellular domain of Jagged1 can physically interact with Notch1, Notch2, and Notch3 in binding assays ( 23 , 24 ).
Journal J. Biol. Chem
Journal Reference v278 i10 p8771 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/10/8771
Source Curated

MedLine Reference 10551863:1013
Sentence Finally, solid-phase binding assay showed that Jagged1 binds to Notch1 and Notch3 in addition to Notch2, suggesting that mJagged1 is a ligand for multiple Notch receptors.
Journal J. Biol. Chem
Journal Reference v274 i46 p32961 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/46/32961
Organism Mus musculus
Source Curated
CellLineName BaF3

MedLine Reference 15574878:1273
Sentence Furthermore, we propose that although fringe glycosylation does not prevent J1 binding to N1, the resultant ligand??receptor interactions do not effectively promote proteolysis required for activation of downstream signaling events.
Journal Mol. Biol. Cell
Journal Reference v16 i2 p927 (2004)
Journal Link http://www.molbiolcell.org/cgi/content/full/16/2/927
Source Curated
CellLineName N1

MedLine Reference 12496248:1306
Sentence Soluble forms of Jagged1 have been reported to physically interact with Notch1, 2, and 3 receptors, indicating that Jex molecules should be capable of binding to endogenous Notch proteins in RKE cells ( 24 ).
Journal J. Biol. Chem
Journal Reference v278 i10 p8771 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/10/8771
Source Curated
CellLineName RKE

MedLine Reference 10551863:1235
Sentence Interaction of Jagged1 with Notch1 and Notch3-- The solid-phase binding assay using purified and immobilized FE-J1-Flag(His) 6 allowed the evaluation of its association with Notch proteins other than mNotch2, namely mNotch1 and mNotch3.
Journal J. Biol. Chem
Journal Reference v274 i46 p32961 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/46/32961
Organism Mus musculus
Source Curated
CellLineName 32D

MedLine Reference 15574878:1113
Sentence Delta1 and Jagged1 Binding to Notch1 in the Presence of Mammalian Fringe Proteins Does Not Directly Correlate with Changes in Notch1 Signaling Previous results have correlated the modulation of Notch signaling by DFng with ligand binding to Notch (Bruckner et al ., 2000 ; Lei et al ., 2003 ; Okajima et al ., 2003 ).
Journal Mol. Biol. Cell
Journal Reference v16 i2 p927 (2004)
Journal Link http://www.molbiolcell.org/cgi/content/full/16/2/927
Source Curated

MedLine Reference 15574878:1013
Sentence Our data support the idea that fringe glycosylation increases Delta1 binding to potentiate signaling, but we propose that although fringe glycosylation does not reduce Jagged1 binding to Notch1, the resultant ligand??receptor interactions do not effectively promote Notch1 proteolysis required for activation of downstream signaling events.
Journal Mol. Biol. Cell
Journal Reference v16 i2 p927 (2004)
Journal Link http://www.molbiolcell.org/cgi/content/full/16/2/927
Source Curated
CellLineName NIH 3T3

MedLine Reference 11427524:1194
Sentence Although it is unclear how the soluble form of Jagged 1 interacts with Notch 1 and Notch 2 on the surface of the NIH 3T3 cell, it is likely that the NIH 3T3 cell may be able to overcome the putative requirements for ligand immobilization and enable the soluble form of Jagged 1 to function as a repressor of its full-length precursor form.
Journal J. Biol. Chem
Journal Reference v276 i34 p32022 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/34/32022
Organism Mus musculus
Source Curated
CellLineName NIH 3T3

MedLine Reference 11006133
Source Curated